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KMID : 1144820180240030157
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대한의생명과학회지
2018 Volume.24 No. 3 p.157 ~ p.167
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Current Status of the Clinical Development of Gene Therapy
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Kwon Sun-Il
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Abstract
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The concept of gene therapy is to treat a disease by transferring therapeutic nucleic acids to a patient's cells. It took several decades from the basic theoretical proposal of gene therapy to the current promising treatment option for some important human diseases. The encountered adverse effects in the early clinical studies boosted the development of sophisticated vectors and elaborate clinical designs. The gene therapy is now considered to have the potential to cure many diseases that are incurable with conventional medications. By the end of 2017, about 2,600 clinical trials of gene therapy have been performed or are ongoing for a variety of diseases such as cancers, monogenic diseases, cardiovascular diseases and neurological diseases etc. Here, we present a brief introduction of technical achievement in relation to gene therapy development, and a review of the current status of global gene therapy clinical development.
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KEYWORD
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Gene therapy, Cancer, Clinical study, Vector, Target diseases, Guidelines
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